Estadísticas de la Primera División de España: Tarjetas - 2021/2022
- Temporada:
| Jugador | Equipo | Amarillas | Rojas | Puntos | |
| 1 | Omar Alderete | Valencia | 15 | 0 | 15 |
| Geoffrey Kondogbia | Atlético Madrid | 11 | 2 | 15 | |
| Omar Alderete | Valencia | 15 | 0 | 15 | |
| Geoffrey Kondogbia | Atlético Madrid | 11 | 2 | 15 | |
| 5 | Hugo Guillamón | Valencia | 9 | 2 | 13 |
| Santi Comesaña | Rayo Vallecano | 11 | 1 | 13 | |
| Mauro Arambarri | Getafe | 13 | 0 | 13 | |
| Djené | Getafe | 11 | 1 | 13 | |
| Rubén Duarte | Alavés | 11 | 1 | 13 | |
| Damián Suárez | Getafe | 13 | 0 | 13 | |
| Óscar Trejo | Rayo Vallecano | 13 | 0 | 13 | |
| Hugo Guillamón | Valencia | 9 | 2 | 13 | |
| Santi Comesaña | Rayo Vallecano | 11 | 1 | 13 | |
| Mauro Arambarri | Getafe | 13 | 0 | 13 | |
| Djené | Getafe | 11 | 1 | 13 | |
| Rubén Duarte | Alavés | 11 | 1 | 13 | |
| Damián Suárez | Getafe | 13 | 0 | 13 | |
| Óscar Trejo | Rayo Vallecano | 13 | 0 | 13 | |
| 19 | Gavi | Barcelona | 10 | 1 | 12 |
| Iñigo Martínez | Athletic Club | 8 | 2 | 12 | |
| Germán | Granada | 10 | 1 | 12 | |
| Iván Balliu | Rayo Vallecano | 10 | 1 | 12 | |
| Stefan Savic | Atlético Madrid | 12 | 0 | 12 | |
| Sergio Busquets | Barcelona | 12 | 0 | 12 | |
| Gavi | Barcelona | 10 | 1 | 12 | |
| Iñigo Martínez | Athletic Club | 8 | 2 | 12 | |
| Germán | Granada | 10 | 1 | 12 | |
| Iván Balliu | Rayo Vallecano | 10 | 1 | 12 | |
| Stefan Savic | Atlético Madrid | 12 | 0 | 12 | |
| Sergio Busquets | Barcelona | 12 | 0 | 12 |