| Arik Armstead91 | DE | 25 | 2.01 m | 132 kg | 5 | Oregon |
| Ronald Blair III98 | DE | 26 | 1.93 m | 122 kg | 4 | Appalachian State |
| Nick Bosa97 | DE | 21 | 1.93 m | 120 kg | N | Ohio State |
| DeForest Buckner99 | DE | 25 | 2.01 m | 136 kg | 4 | Oregon |
| Jamell Garcia-Williams99 | DE | - | 2.03 m | 115 kg | N | UAB |
| Kapron Lewis-Moore89 | DE | 29 | 1.93 m | 142 kg | 4 | Notre Dame |
| Kentavius Street95 | DE | 23 | 1.88 m | 130 kg | 1 | North Carolina State |
| Solomon Thomas94 | DE | 23 | 1.88 m | 127 kg | 3 | Stanford |
| Sheldon Day96 | DT | 24 | 1.85 m | 133 kg | 4 | Notre Dame |
| Kevin Givens30 | DT | 22 | 1.85 m | 129 kg | N | Penn State |
| D.J. Jones93 | DT | 24 | 1.83 m | 145 kg | 3 | Ole Miss |
| Jullian Taylor77 | DT | 24 | 1.96 m | 127 kg | 2 | Temple |
| Cedric Thornton63 | DT | 31 | 1.93 m | 131 kg | 7 | Southern Arkansas |
| Azeez Al-Shaair2 | LB | 21 | 1.88 m | 103 kg | N | Florida Atlantic |
| Kwon Alexander58 | LB | 24 | 1.85 m | 102 kg | 5 | LSU |
| Dee Ford55 | LB | 28 | 1.88 m | 114 kg | 6 | Auburn |
| Dre Greenlaw23 | LB | 22 | 1.83 m | 102 kg | N | Arkansas |
| Elijah Lee47 | LB | 23 | 1.88 m | 103 kg | 3 | Kansas State |
| David Mayo55 | LB | 25 | 1.88 m | 111 kg | 5 | Texas State |
| Mark Nzeocha53 | LB | 29 | 1.91 m | 108 kg | 5 | Wyoming |
| LaRoy Reynolds50 | LB | 28 | 1.85 m | 108 kg | 7 | Virginia |
| Malcolm Smith51 | LB | 29 | 1.83 m | 102 kg | 9 | USC |
| Fred Warner48 | LB | 22 | 1.91 m | 107 kg | 2 | BYU |
| Alex Brown30 | CB | - | 1.8 m | 77 kg | N | South Carolina State |
| Adrian Colbert27 | CB | 25 | 1.88 m | 92 kg | 3 | Miami (FL) |
| Tim Harris21 | CB | - | 1.88 m | 89 kg | N | Virginia |
| Dontae Johnson38 | CB | 27 | 1.88 m | 90 kg | 6 | North Carolina State |
| Greg Mabin26 | CB | 25 | 1.85 m | 90 kg | 3 | Iowa |
| Emmanuel Moseley42 | CB | 23 | 1.8 m | 83 kg | 2 | Tennessee |
| D.J. Reed32 | CB | 22 | 1.75 m | 85 kg | 2 | Kansas State |
| Richard Sherman25 | CB | 31 | 1.91 m | 88 kg | 9 | Stanford |
| Jason Verrett22 | CB | 28 | 1.78 m | 85 kg | 6 | TCU |
| Jimmie Ward20 | CB | 27 | 1.8 m | 87 kg | 6 | Northern Illinois |
| K'Waun Williams24 | CB | 27 | 1.75 m | 83 kg | 5 | Pittsburgh |
| Ahkello Witherspoon23 | CB | 24 | 1.88 m | 88 kg | 3 | Colorado |
| Antone Exum Jr.38 | S | 28 | 1.83 m | 99 kg | 6 | Virginia Tech |
| Demetrius Flannigan-Fowles6 | S | - | 1.88 m | 94 kg | N | Arizona |
| Marcell Harris36 | S | 25 | 1.83 m | 94 kg | 2 | Florida |
| Tarvarius Moore33 | S | 22 | 1.88 m | 90 kg | 2 | Southern Miss |
| Tyree Robinson49 | S | 25 | 1.88 m | 97 kg | 1 | Oregon |
| Jaquiski Tartt29 | S | 27 | 1.85 m | 97 kg | 5 | Samford |
