| Pitcheo | |||||||||||||||||
| POS | JUGADOR | EQUIPO | JJ | GA | EL | H | D | CL | BB | P | G | P | SALV | BLSV | WAR | BBHEL | PCL |
| 1 | Paul Skenes | PIT | 32 | 32 | 187.2 | 136 | 45 | 41 | 42 | 216 | 10 | 10 | 0 | 0 | 7.6 | 0.95 | 1.97 |
| 2 | Tarik Skubal | DET | 31 | 31 | 195.1 | 141 | 55 | 48 | 33 | 241 | 13 | 6 | 0 | 0 | 6.6 | 0.89 | 2.21 |
| 3 | Hunter Brown | HOU | 31 | 31 | 185.1 | 133 | 55 | 50 | 57 | 206 | 12 | 9 | 0 | 0 | 6.1 | 1.03 | 2.43 |
| 4 | Yoshinobu Yamamoto | LAD | 30 | 30 | 173.2 | 113 | 53 | 48 | 59 | 201 | 12 | 8 | 0 | 0 | 5.0 | 0.99 | 2.49 |
| 5 | Cristopher Sanchez | PHI | 32 | 32 | 202.0 | 171 | 58 | 56 | 44 | 212 | 13 | 5 | 0 | 0 | 8.0 | 1.06 | 2.50 |
| 6 | Garrett Crochet | BOS | 32 | 32 | 205.1 | 165 | 62 | 59 | 46 | 255 | 18 | 5 | 0 | 0 | 6.3 | 1.03 | 2.59 |
| 7 | Freddy Peralta | MIL | 33 | 33 | 176.2 | 124 | 54 | 53 | 66 | 204 | 17 | 6 | 0 | 0 | 5.5 | 1.08 | 2.70 |
| 8 | Max Fried | NYY | 32 | 32 | 195.1 | 164 | 73 | 62 | 51 | 189 | 19 | 5 | 0 | 0 | 4.5 | 1.10 | 2.86 |
| 9 | Andrew Abbott | CIN | 29 | 29 | 166.1 | 148 | 60 | 53 | 43 | 149 | 10 | 7 | 0 | 0 | 5.6 | 1.15 | 2.87 |
| 10 | Nick Pivetta | SD | 31 | 31 | 181.2 | 129 | 63 | 58 | 50 | 190 | 13 | 5 | 0 | 0 | 5.3 | 0.99 | 2.87 |
| POS | JUGADOR | EQUIPO | JJ | GA | EL | H | D | CL | BB | P | G | P | SALV | BLSV | WAR | BBHEL | PCL |
| 11 | Bryan Woo | SEA | 30 | 30 | 186.2 | 137 | 64 | 61 | 36 | 198 | 15 | 7 | 0 | 0 | 4.3 | 0.93 | 2.94 |
| 12 | Jacob deGrom | TEX | 30 | 30 | 172.2 | 122 | 57 | 57 | 37 | 185 | 12 | 8 | 0 | 0 | 2.9 | 0.92 | 2.97 |
| 13 | Gavin Williams | CLE | 31 | 31 | 167.2 | 130 | 62 | 57 | 83 | 173 | 12 | 5 | 0 | 0 | 3.8 | 1.27 | 3.06 |
| 14 | Carlos Rodon | NYY | 33 | 33 | 195.1 | 132 | 74 | 67 | 73 | 203 | 18 | 9 | 0 | 0 | 4.6 | 1.05 | 3.09 |
| 15 | Matthew Boyd | CHC | 31 | 31 | 179.2 | 154 | 69 | 64 | 42 | 154 | 14 | 8 | 0 | 0 | 2.6 | 1.09 | 3.21 |
| 16 | Logan Webb | SF | 34 | 34 | 207.0 | 210 | 82 | 74 | 46 | 224 | 15 | 11 | 0 | 0 | 3.9 | 1.24 | 3.22 |
| 17 | Brayan Bello | BOS | 29 | 28 | 166.2 | 147 | 71 | 62 | 59 | 124 | 11 | 9 | 0 | 0 | 2.4 | 1.24 | 3.35 |
| 18 | Joe Ryan | MIN | 31 | 30 | 171.0 | 138 | 69 | 65 | 39 | 194 | 13 | 10 | 0 | 0 | 4.5 | 1.04 | 3.42 |
| 19 | Merrill Kelly | ARI/TEX | 32 | 32 | 184.0 | 157 | 79 | 72 | 48 | 167 | 12 | 9 | 0 | 0 | 2.9 | 1.11 | 3.52 |
| 20 | Clay Holmes | NYM | 33 | 31 | 165.2 | 150 | 74 | 65 | 66 | 129 | 12 | 8 | 0 | 0 | 2.0 | 1.30 | 3.53 |
| POS | JUGADOR | EQUIPO | JJ | GA | EL | H | D | CL | BB | P | G | P | SALV | BLSV | WAR | BBHEL | PCL |
| 21 | Luis Castillo | SEA | 32 | 32 | 180.2 | 168 | 76 | 71 | 46 | 162 | 11 | 8 | 0 | 0 | 2.1 | 1.18 | 3.54 |
| 22 | Kevin Gausman | TOR | 32 | 32 | 193.0 | 155 | 79 | 77 | 50 | 189 | 10 | 11 | 0 | 0 | 3.8 | 1.06 | 3.59 |
| 23 | Robbie Ray | SF | 32 | 32 | 182.1 | 148 | 81 | 74 | 73 | 186 | 11 | 8 | 0 | 0 | 2.8 | 1.21 | 3.65 |
| 24 | Framber Valdez | HOU | 31 | 31 | 192.0 | 171 | 82 | 78 | 68 | 187 | 13 | 11 | 0 | 0 | 3.8 | 1.24 | 3.66 |
| 25 | Zack Littell | TB/CIN | 32 | 32 | 186.2 | 174 | 81 | 79 | 32 | 130 | 10 | 8 | 0 | 0 | 3.2 | 1.10 | 3.81 |
| 26 | Michael Wacha | KC | 31 | 31 | 172.2 | 166 | 74 | 74 | 45 | 126 | 10 | 13 | 0 | 0 | 2.8 | 1.22 | 3.86 |
| 27 | Ryan Pepiot | TB | 31 | 31 | 167.2 | 134 | 77 | 72 | 61 | 167 | 11 | 12 | 0 | 0 | 1.9 | 1.16 | 3.86 |
| 28 | Jesus Luzardo | PHI | 32 | 32 | 183.2 | 167 | 85 | 80 | 57 | 216 | 15 | 7 | 0 | 0 | 3.9 | 1.22 | 3.92 |
| 29 | Chris Bassitt | TOR | 32 | 31 | 170.1 | 174 | 80 | 75 | 52 | 166 | 11 | 9 | 0 | 0 | 2.1 | 1.33 | 3.96 |
| 30 | Yusei Kikuchi | LAA | 33 | 33 | 178.1 | 180 | 87 | 79 | 74 | 174 | 7 | 11 | 0 | 0 | 3.3 | 1.42 | 3.99 |
| POS | JUGADOR | EQUIPO | JJ | GA | EL | H | D | CL | BB | P | G | P | SALV | BLSV | WAR | BBHEL | PCL |
| 31 | Brady Singer | CIN | 32 | 32 | 169.2 | 150 | 80 | 76 | 60 | 163 | 14 | 12 | 0 | 0 | 3.1 | 1.24 | 4.03 |
| 32 | Jeffrey Springs | ATH | 32 | 30 | 171.0 | 153 | 90 | 78 | 54 | 138 | 11 | 11 | 0 | 0 | 1.9 | 1.21 | 4.11 |
| 33 | Jose Berrios | TOR | 31 | 30 | 166.0 | 160 | 86 | 77 | 56 | 138 | 9 | 5 | 0 | 0 | 1.3 | 1.30 | 4.17 |
| 34 | Mitch Keller | PIT | 32 | 32 | 176.1 | 171 | 91 | 82 | 51 | 150 | 6 | 15 | 0 | 0 | 1.4 | 1.26 | 4.19 |
| 35 | Dean Kremer | BAL | 31 | 29 | 171.2 | 163 | 83 | 80 | 45 | 142 | 11 | 10 | 0 | 0 | 2.1 | 1.21 | 4.19 |
| 36 | David Peterson | NYM | 30 | 30 | 168.2 | 166 | 84 | 79 | 65 | 150 | 9 | 6 | 0 | 0 | 1.4 | 1.37 | 4.22 |
| 37 | Tanner Bibee | CLE | 31 | 31 | 182.1 | 170 | 93 | 86 | 54 | 162 | 12 | 11 | 0 | 0 | 1.1 | 1.23 | 4.24 |
| 38 | Jose Soriano | LAA | 31 | 31 | 169.0 | 158 | 89 | 80 | 78 | 152 | 10 | 11 | 0 | 0 | 2.3 | 1.40 | 4.26 |
| 39 | Sonny Gray | STL | 32 | 32 | 180.2 | 185 | 93 | 86 | 38 | 201 | 14 | 8 | 0 | 0 | 1.4 | 1.23 | 4.28 |
| 40 | Will Warren | NYY | 33 | 33 | 162.1 | 158 | 90 | 80 | 65 | 171 | 9 | 8 | 0 | 0 | 0.6 | 1.37 | 4.44 |
WAR data provided by Baseball-Reference