Athletic Bilbao are without a LaLiga win at Espanyol for 18 years following a goalless draw at RCDE Stadium.
Bilbao may have beaten Genk 5-3 in the Europa League on Thursday night but they could not find the net here and had to settle for a second consecutive league stalemate.
The draw was Espanyol's fourth in five matches and they sit 13th in the table, five points behind seventh-placed Bilbao.
It was a positive start by Espanyol as Leo Baptistao sent a header over.
In the 30th minute, Quique Sanchez Flores' side created another opening as midfielder Pablo Piatti saw a left-footed shot from just outside the Bilbao penalty area saved by Kepa Arrizabalaga.
The hosts remained on the front foot as David Lopez set up a chance for Gerard Moreno, whose angled shot just missed the top-left corner.
Bilbao were forced into a change with seven minutes left of the first half when centre-back Xabier Etxeita hobbled off with a knee injury and was replaced by Oscar De Marcos.
Espanyol finished the first half strongly, as Piatti again tested Arrizabalaga with a 20-yard effort.
Following the restart, Espanyol continued to press.
Piatti was this time the provider as his delivery picked out Javi Fuego and the midfielder's header was just wide.
Aritz Aduriz scored all five goals against Genk but, when he found himself with an opening after being set up by Mikel Rico on the hour, the forward could only send his shot too high.
Bilbao had the better of the closing exchanges, with substitute Raul Garcia and Javier Eraso both off target from long range.
In stoppage time, Gerard found a chance to win it for Espanyol, but his close-range header was saved.
ends